Publication
Title
Risk of depressive symptoms in the oldest old subjects with chronic obstructive pulmonary disease : the Leiden 85-Plus Study
Author
Abstract
Objectives: Chronic obstructive pulmonary disease (COPD) has been associated with depression in middle-aged and younger old adults. However, it remains unknown whether COPD contributes to the occurrence of depressive symptoms in the oldest old subjects. The authors aimed to determine whether oldest old persons with COPD are at increased risk of developing depressive symptoms. Design, Setting, Participants: The authors prospectively followed up 333 subjects from age 85 years onward within the population-based Leiden 85-plus Study. COPD, along with other chronic diseases, was assessed using structured questionnaires and confirmed with the diagnosis of the treating physician. Depressive symptoms were assessed annually using the 15-item version of the Geriatric Depression Scale (GDS-15). Nondepressed subjects with and without COPD at baseline were compared for the occurrence of depressive symptoms during 5 years of follow-up using multilevel analysis. Results: At baseline, COPD was present in 40 subjects (12%) and associated with male gender, lower education, and smoking. During 5 years of follow-up, an additional annual increase of 0.29 points (standard error [SE] = 0.14) in the GDS-score was observed in subjects with COPD, when compared with those without COPD (F([1, 212]) = 4.1, p = 0.04). This difference persisted after adjustment for demographics, baseline GDS score, functional limitations, and presence of chronic diseases (F([1, 451]) = 4.6, p = 0.03). Conclusion: In the oldest old subjects, COPD independently contributes to an increased risk of developing depressive symptoms. Clinicians should be aware of the association of COPD with depressive symptoms in the oldest old to offer them optimal treatment in an early stage. (Am J Geriatr Psychiatry 2010; 18: 388-394)
Language
English
Source (journal)
American journal of geriatric psychiatry. - Arlington, Va
Publication
Arlington, Va : 2010
ISSN
1064-7481
DOI
10.1097/JGP.0B013E3181CA8241
Volume/pages
18 :5 (2010) , p. 388-394
ISI
000277307000004
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 17.11.2016
Last edited 16.02.2023
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