Publication
Title
Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age
Author
Abstract
The association between inflammation and neuropsychiatric symptoms in old age is generally accepted but poorly understood. The purpose of this study was to examine whether inflammation precedes depressive symptoms and cognitive decline in old age, and to identify specific inflammatory pathways herein. We measured serum C-reactive protein (CRP) and lipopolysaccharide-induced production of Interleukin (IL)-1 beta, IL-6, Tumor Necrosis Factor (TNF)-alpha, IL-1 receptor antagonist (ra), and IL-10 levels in 85-year-old participants free from neuropsychiatric symptoms at baseline (n = 267). Participants were prospectively followed for depressive symptoms (Geriatric Depression Scale) and cognitive functioning (Mini Mental State Examination) from 85 to 90 years. Higher baseline CRP levels preceded accelerated increase in depressive symptoms (p < 0.001). A higher production capacity of the pro-inflammatory cytokine IL-1 beta preceded a greater increase of depressive symptoms (p = 0.06), whereas that of its natural antagonist IL-1ra preceded a smaller increase of depressive symptoms (p = 0.003). There was no relation of CRP, IL-1 beta, and IL-1ra with cognitive decline. Our findings show that in old age inflammatory processes contribute to the development of depressive symptoms but not cognitive decline. A high innate IL-1ra to IL-1 beta production capacity reflects a better ability to neutralize inflammation and may therefore protect against depressive symptoms. (C) 2007 Elsevier Inc. All rights reserved.
Language
English
Source (journal)
Experimental gerontology. - Oxford
Publication
Oxford : 2007
ISSN
0531-5565
DOI
10.1016/J.EXGER.2007.01.011
Volume/pages
42 :7 (2007) , p. 693-701
ISI
000247438500014
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 17.11.2016
Last edited 01.02.2023
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