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Title
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Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years
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Author
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Abstract
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| This study examines the intra-individual stability of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) over 2 years in 83 patients with mild cognitive impairment (MCI) and 17 cognitively healthy control individuals. All participants underwent clinical and neuropsychological evaluation and lumbar puncture at baseline and after 2 years at a university hospital memory clinic. CSF was analyzed for total tau (T-tau), phospho-tau_{181} (P-tau_{181}) and amyloid-β _{1-42} (Aβ_{1-42}). During the 2-year observational time, 12 MCI patients progressed to AD and 3 progressed to vascular dementia, while 68 remained stable. Baseline T-tau and P-tau_{181} levels were elevated in the MCI-AD group as compared to the stable MCI patients and the control group (p<0.01), while baseline Aβ_{1-42} levels were lower (p<0.001). Stable MCI patients were biochemically indistinguishable from controls. The biomarker levels at baseline and after 2 years showed Pearson R values between 0.81 and 0.91 (p<0.001) and coefficients of variation of 7.2 to 8.7%. In conclusion, intra-individual biomarker levels are remarkably stable over 2 years. Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials. |
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Language
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English
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Source (journal)
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Journal of Alzheimer's disease. - -
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Publication
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2007
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ISSN
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1387-2877
1875-8908
[Electronic]
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DOI
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10.3233/JAD-2007-12307
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Volume/pages
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12
:3
(2007)
, p. 255-260
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ISI
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000252300000007
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Full text (Publisher's DOI)
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