Title
|
|
|
|
P2Y12 receptor inhibitors in patients with non-ST-elevation acute coronary syndrome in the real world : use, patient selection, and outcomes from contemporary European registries
| |
Author
|
|
|
|
| |
Institution/Organisation
|
|
|
|
PIRAEUS Grp
| |
Abstract
|
|
|
|
Aims Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. Methods and results A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic manner on patient characteristics and outcomes for NSTE-ACS in general, and 6 of these (with 52 173 NSTE-ACS patients) also provided more specific data according to P2Y12 receptor inhibitor used. Unadjusted analyses were performed at the study level, and no formal meta-analysis was performed due to large heterogeneity between studies in the settings, patient characteristics, and outcome definitions. All-cause death rates across registries ranged from 0.76 to 4.79% in-hospital, from 1.61 to 6.65% at 30 days, from 3.66 to 7.16% at 180 days, and from 3.14 to 9.73% at 1 year. Major bleeding events were reported in up to 2.77% of patients while in hospital (in seven registries), up to 1.08% at 30 days (data from one registry only), and 2.06% at 1 year (one registry). Conclusions There were substantial differences in the use of and patient selection for clopidogrel, prasugrel, and ticagrelor, which were associated with differences in short-and long-term ischaemic and bleeding events. In future registries, data collection should be performed in a more standardized way with respect to endpoints, definitions, and time points. |
| |
Language
|
|
|
|
English
| |
Source (journal)
|
|
|
|
European heart journal. Cardiovascular pharmacotherapy
| |
Publication
|
|
|
|
2016
| |
ISSN
|
|
|
|
2055-6837
| |
DOI
|
|
|
|
10.1093/EHJCVP/PVW005
| |
Volume/pages
|
|
|
|
2
:4
(2016)
, p. 229-243
| |
ISI
|
|
|
|
000383338600025
| |
Pubmed ID
|
|
|
|
27533946
| |
Full text (Publisher's DOI)
|
|
|
|
| |
Full text (open access)
|
|
|
|
| |
Full text (publisher's version - intranet only)
|
|
|
|
| |
|