Title
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Effects of oral bovine colostrum supplementation on serum insulin-like growth factor-I levels
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Author
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Abstract
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OBJECTIVES: We investigated whether supplementation with 60 g/d of bovine colostrum affects blood levels of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 in relation to doping testing. Nine endurance-trained men ingested 60 g/d of bovine colostrum for 4 wk. METHODS: Blood and urine were sampled before starting supplementation. After 4 wk urine and blood samples were taken after an overnight fast and 2 h after ingestion of the last portion to study possible acute effects. RESULTS: Blood IGF-1 levels before supplementation were (mean +/- standard deviation) 31 +/- 13 nM/L, and no acute effects were observed after 4 wk of supplementation (33 +/- 9 nM/L). Levels of IGF-binding protein-3 were 136 +/- 11 nM/L before supplementation and 135 +/- 16 nM/L after 4 wk of supplementation. Two hours after ingestion of the last portion, the level of IGF binding protein-3 was 131 +/- 19 nM/L, which was not different from baseline values. Drug testing in a laboratory accredited by the International Olympic Committee did not show any forbidden substance before or after 4 wk of supplementation. CONCLUSIONS: Daily supplementation with 60 g of bovine colostrum for 4 wk does not change blood IGF-1 or IGF binding protein-3 levels and does not elicit positive results on drug tests. |
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Language
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English
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Source (journal)
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Nutrition. - Burbank, Calif.
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Publication
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Burbank, Calif.
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2002
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ISSN
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0899-9007
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DOI
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10.1016/S0899-9007(02)00800-6
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Volume/pages
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18
:7-8
(2002)
, p. 566-567
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Article Reference
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PII S0899-9007(02)00800-6
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ISI
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000176593700005
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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