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Title
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Neurogenic radial glia-like cells in meninges migrate and differentiate into functionally integrated neurons in the neonatal cortex
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Author
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Abstract
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| Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and differentiate into Satb2+ neurons in cortical layers IIIV. The resulting neurons are electrically functional and integrated into local microcircuits. Single-cell RNA sequencing identified meningeal cells with distinct transcriptome signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in the SVZ), (2) neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neuronal cells. Thus, we have identified a pool of embryonically derived radial glia-like cells present in the meninges that migrate and differentiate into functional neurons in the neonatal cerebral cortex. |
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Language
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English
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Source (journal)
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Cell stem cell. - Place of publication unknown
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Publication
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Place of publication unknown
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2017
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ISSN
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1934-5909
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DOI
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10.1016/J.STEM.2016.10.020
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Volume/pages
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20
:3
(2017)
, p. 360-+
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ISI
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000396375300011
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Pubmed ID
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27889318
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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