|
Title
|
|
|
|
Rat heart fatty acid-binding protein content is increased in experimental diabetes
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Cytoplasmic fatty acid-binding protein (FABP) was assayed immunochemically in hearts from rats with insulin-dependent (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM). FABP contents were 34% higher in IDDM and 103% higher in NIDDM hearts than in respective age-matched controls. FABP levels returned to control values when islets of Langerhans were transplanted into diabetic IDDM animals. In the diabetic hearts the activity of fructose-6-phosphate kinase decreased (IDDM and NIDDM animals), while that of 3-hydroxyacyl-CoA dehydrogenase increased (NIDDM animals only). These data indicate that experimental diabetes induces a marked increase of the FABP content of rat heart and suggests that this protein is involved in the enhanced fatty acid utilization by the diabetic heart. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Biochemical and biophysical research communications. - New York, N.Y.
|
|
|
Publication
|
|
|
|
New York, N.Y.
:
1994
|
|
|
ISSN
|
|
|
|
0006-291X
|
|
|
DOI
|
|
|
|
10.1006/BBRC.1994.1276
|
|
|
Volume/pages
|
|
|
|
199
:2
(1994)
, p. 639-646
|
|
|
ISI
|
|
|
|
A1994NA91400031
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|