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Title
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Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles
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Author
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Abstract
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| We report a highly diastereoselective interrupted Ugi reaction to construct a broad range of structurally congested and stereo-chemically complex spiroindolines from tryptamine-derived isocyanides. The reaction is facilitated by using fluorinated alcohols (TFE or HFIP) as solvents and tolerates a broad range of amines, aldehydes and 2-isocyanoethylindoles to give polycyclic products in moderate to excellent yields. |
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Language
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English
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Source (journal)
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Chemical communications / Royal Society of Chemistry [London] - London, 1996, currens
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Publication
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London
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Royal Society of Chemistry
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2016
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ISSN
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1359-7345
[print]
1364-548X
[online]
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DOI
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10.1039/C6CC07459F
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Volume/pages
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52
:84
(2016)
, p. 12482-12485
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ISI
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000386221900019
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Pubmed ID
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27722446
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Full text (Publisher's DOI)
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