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Title
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Patient engagement impacts glycemic management with vildagliptin and vildagliptin/metformin (single pill) regimens in type 2 diabetes mellitus (the GLORIOUS study)
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Author
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Abstract
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| Aims: To evaluate the real-world effectiveness of vildagliptin and vildagliptin/metformin, combined with patient engagement, on glycemic outcomes. Patient engagement included both clinicians' engaging patients through education and counseling; and patients' self engagement through disease awareness, lifestyle changes, and medication adherence. Methods: Prospective, observational, open-label, multi-center, pharmacoepidemiologic study of type 2 diabetes mellitus (T2DM) patients treated de novo with vildagliptin or vildagliptin/metformin. Data were collected at baseline (treatment initiation), 105 +/- 15 d, and >= 145 d. Results: The evaluable sample included 896 mainly male (58%), overweight (mean +/- SD BMI =30.3 +/- 5.4 kg/m(2)), in later middle age (mean +/- SD age = 64 +/- 11years) patients. Over the three visits, mean(SD) HbA1c levels declined from 8.1%(+/- 1.0) to 7.3%(+/- 1.0) to 7.2%(+/- 0.9); HbA1c control rates rose from 7% to 36% to 43%. Mean +/- SD FPG levels decreased from 170(+/- 49) to 141(+/- 41) to 139(+/- 42) mg/dL; control rates increased from 12% to 39% to 43% (all p <0.0001). Weight decreased nominally by 2 kg (p = 0.0290) and BMI by 0.8 kg/m(2) (p < 0.0001). Modeling showed patient engagement activities by clinicians and by patients to be major determinants of glycemic outcomes. No unknown safety signals were detected. Conclusions: Vildagliptin and vildagliptin/metformin are effective and safe oral agents in the management of T2DM, especially if part of a treatment program with active patient engagement by clinicians and empowered patients. (C) 2016 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Primary care diabetes. - Place of publication unknown
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Publication
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Place of publication unknown
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2016
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ISSN
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1751-9918
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DOI
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10.1016/J.PCD.2016.05.008
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Volume/pages
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10
:6
(2016)
, p. 425-433
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ISI
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000389103000005
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Pubmed ID
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27388795
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Full text (Publisher's DOI)
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