|
Title
|
|
|
|
Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis
| |
|
Author
|
|
|
|
| |
|
Institution/Organisation
|
|
|
|
Thrombolysis Stroke Patients TriSP
| |
|
Abstract
|
|
|
|
| Background and purposeThe impact of body mass index (BMI) on outcome in stroke patients treated with intravenous thrombolysis (IVT) was investigated. MethodsIn a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage (sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m(2)) from underweight (<18.5 kg/m(2)), overweight (25-29.9 kg/m(2)) and obese (30 kg/m(2)) patients. Univariable and multivariable regression analyses with adjustments for age and stroke severity were done and odds ratios with 95% confidence intervals [OR (95% CI)] were calculated. ResultsOf 1798 patients, 730 (40.6%) were normal weight, 55 (3.1%) were underweight, 717 (39.9%) overweight and 295 (16.4%) obese. Poor outcome occurred in 38.1% of normal weight patients and did not differ significantly from underweight (45.5%), overweight (36.1%) and obese (32.5%) patients. The same was true for death (9.5% vs. 14.5%, 9.6% and 7.5%) and sICH (3.9% vs. 5.5%, 4.3%, 2.7%). Neither in univariable nor in multivariable analyses did the risks of poor outcome, death or sICH differ significantly between BMI groups. BMI as a continuous variable was not associated with poor outcome, death or sICH in unadjusted [OR (95% CI) 0.99 (0.97-1.01), 0.98 (0.95-1.02), 0.98 (0.94-1.04)] or adjusted analyses [OR (95% CI) 1.01 (0.98-1.03), 0.99 (0.95-1.05), 1.01 (0.97-1.05)], respectively. ConclusionIn this largest study to date, investigating the impact of BMI in IVT-treated stroke patients, BMI had no prognostic meaning with regard to 3-month functional outcome, death or occurrence of sICH. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
European journal of neurology / European Federation of Neurological Societies. - Oxford
| |
|
Publication
|
|
|
|
Oxford
:
2016
| |
|
ISSN
|
|
|
|
1351-5101
| |
|
DOI
|
|
|
|
10.1111/ENE.13071
| |
|
Volume/pages
|
|
|
|
23
:12
(2016)
, p. 1705-1712
| |
|
ISI
|
|
|
|
000389135300007
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|