Publication
Title
Targeting the gastrointestinal tract with viral vectors: state of the art and possible applications in research and therapy
Author
Abstract
While there is a large body of preclinical data on the use of viral vectors in gene transfer, relatively little is known about viral gene transfer in the gastrointestinal tract. Viral vector technology is especially underused in the field of neurogastroenterology when compared to brain research. This review provides an overview of the studies employing viral vectors-in particular retroviruses, adenoviruses and adeno-associated viruses-to transduce different cell types in the intestine. Early work mainly focused on mucosal transduction, but had limited success due to the harsh luminal conditions in the gastrointestinal tract and the high turnover rate of enterocytes. More recently, several studies have successfully employed viral gene transfer to target the enteric nervous system and its progenitors. Although several hurdles still need to be overcome, in particular on how to augment transduction efficiency and specific cell targeting, viral vector technology holds strong potential not only as a valid research tool in fundamental gastroenterological research but also as a therapeutic agent in translational (bio)medical research.
Language
English
Source (journal)
Histochemistry and cell biology / Society for Histochemistry. - Heidelberg, 1995, currens
Publication
New york : Springer , 2016
ISSN
0948-6143 [print]
1432-119X [online]
DOI
10.1007/S00418-016-1496-6
Volume/pages
146 :6 (2016) , p. 709-720
ISI
000387811700008
Pubmed ID
27665281
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Role of dendritic cells in Th1/Th17-mediated immune diseases.
Prenatal adeno-associated viral transduction of the enteric nervous system as a novel toolbox in neurogastroenterological research.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 10.01.2017
Last edited 09.10.2023
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