Genome sequence of Helicobacter suis supports its role in gastric pathology

Vermoote, Miet; Vandekerckhove, Tom Theo Marie; Flahou, Bram; Pasmans, Frank; Smet, Annemieke; De Groote, Dominic; Van Criekinge, Wim; Ducatelle, Richard; Haesebrouck, Freddy

doi:10.1186/1297-9716-42-51

Title

Genome sequence of Helicobacter suis supports its role in gastric pathology

Author

Vermoote, Miet

Vandekerckhove, Tom Theo Marie

Flahou, Bram

Pasmans, Frank

Smet, Annemieke

De Groote, Dominic

Van Criekinge, Wim

Ducatelle, Richard

Haesebrouck, Freddy

Abstract

Helicobacter (H.) suis has been associated with chronic gastritis and ulcers of the pars oesophagea in pigs, and with gastritis, peptic ulcer disease and gastric mucosa-associated lymphoid tissue lymphoma in humans. In order to obtain better insight into the genes involved in pathogenicity and in the specific adaptation to the gastric environment of H. suis, a genome analysis was performed of two H. suis strains isolated from the gastric mucosa of swine. Homologs of the vast majority of genes shown to be important for gastric colonization of the human pathogen H. pylori were detected in the H. suis genome. H. suis encodes several putative outer membrane proteins, of which two similar to the H. pylori adhesins HpaA and HorB. H. suis harbours an almost complete comB type IV secretion system and members of the type IV secretion system 3, but lacks most of the genes present in the cag pathogenicity island of H. pylori. Homologs of genes encoding the H. pylori neutrophil-activating protein and g-glutamyl transpeptidase were identified in H. suis. H. suis also possesses several other presumptive virulence-associated genes, including homologs for mviN, the H. pylori flavodoxin gene, and a homolog of the H. pylori vacuolating cytotoxin A gene. It was concluded that although genes coding for some important virulence factors in H. pylori, such as the cytotoxin-associated protein (CagA), are not detected in the H. suis genome, homologs of other genes associated with colonization and virulence of H. pylori and other bacteria are present.

Language

English

Source (journal)

Veterinary research. - Paris

Publication

Paris : 2011

ISSN

0928-4249

1297-9716

DOI

10.1186/1297-9716-42-51

Volume/pages