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Title
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Study of antiparasitic and cytotoxicity of the aqueous, the 80% methanol extract and its fractions, and the acute toxicity of the aqueous extract of **Brucea sumatrana** (Simaroubaceae) leaves collected in Mai-Ndombe, Democratic Republic of Congo
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Author
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Abstract
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| Results from the in vitro evaluation of the antiparasitaire activity of the aqueous extract, the 80% methanol extract and its fractions from the leaves of Brucea sumatrana against Trypanosoma brucei brucei , T. cruzi , Leishmania infantum, the multidrugresistant K1 and chloroquine-sensitive NF54 strains of Plasmodium falciparum indicated that all samples from the leaves extract presented interesting antiparasitaire activity at different extents. The 80% methanol extract, its chloroform acid, petroleum ether and 80% methanol soluble fractions and the aqueous extract exhibited strong activity against Trypanosoma b. brucei , T. cruzi , L. infantum and the multidrug- resistant K1 strain of P. falciparum with IC50 values from <0.25 to 4.35 μg/ml as well as against chloroquine-sensitive NF54 strain of P. falciparum with IC50 values ranging from <0.02 to 2.0.4 μg/ml. Most samples were cytotoxic against MRC-5 cell lines (0.2 < cytotoxic concentration 50(CC50) < 34.24 μg/ml) and showed good selective effect against all tested parasites. In acute toxicity, the aqueous extract was found to be non-toxic and its LD50 was estimated to be greater than 5 g/kg. In addition, it did not significantly modify the concentration levels of some evaluated biochemical |
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Language
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English
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Source (journal)
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Chinese Medicine (2151-1918)
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Publication
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2016
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ISSN
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2151-1918
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DOI
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10.4236/CM.2016.73011
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Volume/pages
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7
(2016)
, p. 93-109
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Full text (Publisher's DOI)
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Full text (open access)
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