Publication
Title
Evaluation of the Genotoxicity and Cytotoxicity of Semipurified Fractions from the Mediterranean Brown Algae, Dictyopteris membranacea
Author
Abstract
Dictyopteris membranacea, a species of Mediterranean brown algae, is believed to have potential pharmacological and nutritional applications. However, such potentials only make sense when devoid of any adverse health consequences. The present study should be seen in this context. It aimed at evaluating the genotoxicity and cytoxicity of its organic extract (F-0) and semi purified fractions (F-4, F-5, and F-6). Extracts were tested using the bacterial Vitotox (R) test and micronucleus assay in different concentrations (from 1.25 mu g/mL up to 100 mu g/mL, depending on the test and the extract). Applied concentrations were based on a preliminary dose-finding test with the neutral red uptake assay. The results show that all extracts were not genotoxic in the presence or absence of a rat metabolic enzyme fraction (S9). This is encouraging and justifies further investigations on the therapeutic and other values of this algae.
Language
English
Source (journal)
Pharmacognosy magazine
Publication
2016
ISSN
0973-1296
DOI
10.4103/0973-1296.188318
Volume/pages
12 :47s:[4] (2016) , p. S395-S399
ISI
000391129400002
Pubmed ID
27761065
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 16.02.2017
Last edited 09.10.2023
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