Title
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High susceptibility to cytomegalovirus infection of pregnant women in Flanders, Belgium
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Author
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Abstract
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Maternal antibodies against cytomegalovirus (CMV) infection offer, to some extent, protection against congenital CMV infection. This study describes the seroprevalence of CMV-specific IgG in 220 parturient women during pregnancy, at delivery, at 3 months after delivery and in their cord blood (Flanders, Belgium, 2006-2008). ELISA was used to measure IgG. Of this population, 30% had positive IgG titres. Active transplacental transport was confirmed with a ratio 1.15/1. Elevated maternal IgG titre and increased parity, but not age, were significantly associated with higher seropreva- lence of CMV-specific IgG in the cord blood. These data indicate a high susceptibility to CMV among fertile women. Prenatal prevention and other strategies to prevent intra-uterine infection are of critical importance in a highly susceptible population. |
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Language
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English
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Source (journal)
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Facts, views & vision in obgyn : issues in obstetrics, gynaecology and reproductive health. - Place of publication unknown
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Publication
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Place of publication unknown
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Flemish Society of Obstetrics, Gynaecology & Reproductive Health
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2012
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ISSN
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2032-0418
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Volume/pages
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4
:2
(2012)
, p. 76-81
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Full text (open access)
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