Publication
Title
Safety and efficacy of single-agent bevacizumab-containing therapy in elderly patients with platinum-resistant recurrent ovarian cancer: Subgroup analysis of the randomised phase III AURELIA trial
Author
Institution/Organisation
AURELIA Investigators
Abstract
Background. The AURELIA trial demonstrated significantly improved progression-free survival (PPS) with bevacizumab added to chemotherapy for platinum-resistant ovarian cancer (PROC). Methods. Patients with PROC were randomised to receive investigator-selected single-agent chemotherapy alone or with bevacizumab. Post-hoc exploratory analyses assessed efficacy, safety and patient-reported outcomes according to age <65 versus 265 years. Results. In the 133 patients (37%) aged >= 65 years, baseline hypertension was more frequent and ascites was less common than in patients <65 years. The magnitude of PFS benefit from bevacizumab was similar in patients >= 65 versus <65 years (hazard ratio 0.44 [95% CI, 0.31-0.64] versus 0.49 [95% CI, 037-0.64], respectively, treatment-age interaction p = 0.58), with similar improvements in response rates. Grade >= 3 hypertension was more common with bevacizumab than chemotherapy alone in both subgroups, and more common in older than younger patients irrespective of treatment. However, there was no excess of other adverse events of specific interest for bevacizumab, including venous thromboembolic events, in older patients. More patients receiving bevacizumab in the younger but not the older subgroup showed improved gastrointestinal/abdominal symptoms. Conclusion. In exploratory analyses, PFS and response rate improvement with bevacizumab were consistent in older and younger patients. Grade >= 3 hypertension was more common in elderly bevacizumab-treated patients; careful monitoring is recommended. Overall, bevacizumab-containing therapy was well tolerated in a selected population aged >= 65 years, suggesting a favourable benefit:risk profile. However, geriatric assessments are needed to improve selection of elderly patients potentially gaining symptom and quality of life improvements from bevacizumab-containing therapy. (C) 2016 Elsevier Inc. All rights reserved.
Language
English
Source (journal)
Gynecologic oncology. - New York
Publication
New York : 2017
ISSN
0090-8258
DOI
10.1016/J.YGYNO.2016.11.006
Volume/pages
144 :1 (2017) , p. 65-71
ISI
000392367000013
Pubmed ID
27871723
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 16.03.2017
Last edited 09.10.2023
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