Publication
Title
In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp.
Author
Abstract
The significance of polymicrobial infections is increasingly being recognized especially in a biofilm context wherein multiple bacterial species-including both potential pathogens and members of the commensal flora-communicate, cooperate, and compete with each other. Two important bacterial pathogens that have developed a complex network of evasion, counter-inhibition, and subjugation in their battle for space and nutrients are Pseudomonas aeruginosa and Staphylococcus aureus. Their strain-and environment-specific interactions, for instance in the cystic fibrosis lung or in wound infections, show severe competition that is generally linked to worse patient outcomes. For instance, the extracellular factors secreted by P. aeruginosa have been shown to subjugate S. aureus to persist as small colony variants (SCVs). On the other hand, data also exist where S. aureus inhibits biofilm formation by P. aeruginosa but also protects the pathogen by inhibiting its phagocytosis. Interestingly, such interspecies interactions differ between the planktonic and biofilm phenotype, with the extracellular matrix components of the latter likely being a key, and largely underexplored, influence. This review attempts to understand the complex relationship between P. aeruginosa and Staphylococcus spp., focusing on S. aureus, that not only is interesting from the bacterial evolution point of view, but also has important consequences for our understanding of the disease pathogenesis for better patient management.
Language
English
Source (journal)
Frontiers in cellular and infection microbiology / Informatics (India) Pvt. Ltd. - Lausanne, 2011, currens
Publication
Lausanne : Frontiers media sa , 2017
ISSN
2235-2988
DOI
10.3389/FCIMB.2017.00106
Volume/pages
7 (2017) , 13 p.
Article Reference
106
ISI
000397946300001
Pubmed ID
28421166
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Combatting Bacterial Resistance in Europe - Molecules Against Gram Negative Infections (COMBACTE-MAGNET).
Characterizing host-pathogen interactions and biofilm formation in patients developing pneumonia on assisted ventilation.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.05.2017
Last edited 04.03.2024
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