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Title
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Synthesis of 2,4-dideoxy-beta-d-erythro-hexopyranosyl nucleosides
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Author
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Abstract
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| The synthesis of 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine (12)1 was accomplished using two different synthetic routes. It was obtained starting either from 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose or from tri-O-acetyl-D-glucal. The other modified nucleosides, with either a cytosine, guanine, or adenine moiety, were synthesized using the second reaction scheme. Deoxygenation reactions were accomplished with the (2,4-dichlorophenoxy)thiocarbonyl derivatives generated in situ. |
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Language
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English
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Source (journal)
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The journal of organic chemistry. - Washington, D.C., 1936, currens
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Publication
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Washington, D.C.
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1993
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ISSN
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0022-3263
[print]
1520-6904
[online]
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DOI
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10.1021/JO00063A013
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Volume/pages
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58
:11
(1993)
, p. 2977-2982
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ISI
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A1993LD26200013
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Full text (Publisher's DOI)
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