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Title
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Helicobacter suis induces changes in gastric inflammation and acid secretion markers in pigs of different ages
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Author
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Abstract
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| Gastric mRNA expression of markers for acid secretion and inflammation and presence of gastric ulceration was studied in naturally Helicobacter suis-infected and non-infected 2-3 months old, 6-8 months old and adult pigs. In H. suis-infected 2-3 months old pigs, IL-8 and IL-1 beta transcript levels were upregulated in the pyloric gland zone, indicating an innate immune response. A similar response was demonstrated in the fundic gland zone of adult pigs, potentially due to a shift of H. suis colonization from the pyloric to the fundic gland zone. A Treg response in combination with decreased expressions of IL-8, IL-17A and IFN-gamma was indicated to be present in the H. suis-infected 6-8 months old pigs, which may have contributed to persistence of H. suis. In H. suis-infected adult pigs, a Treg response accompanied by a Th17 response was indicated, which may have played a role in the decreased number of H. suis bacteria in the stomach of this age group. The decreased G-cell mass and upregulated expression of somatostatin indicated decreased acid secretion in H. suis-infected 6-8 months old pigs. In H. suis-infected adult pigs, upregulation of most markers for gastric acid secretion and increased G-cell mass was detected. Presence of severe hyperkeratosis and erosions in the non-glandular part of the stomach were mainly seen in the H. suis-positive groups. These results show that H. suis infection affects the expression of markers for acid secretion and inflammation and indicate that these effects differ depending on the infection phase. |
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Language
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English
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Source (journal)
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Veterinary research. - Paris
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Publication
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Paris
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2017
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ISSN
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0928-4249
1297-9716
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DOI
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10.1186/S13567-017-0441-6
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Volume/pages
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48
(2017)
, 13 p.
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Article Reference
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34
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ISI
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000403838800001
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Pubmed ID
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28619040
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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