Publication
Title
A randomized, controlled trial of positional therapy versus oral appliance therapy for position-dependent sleep apnea
Author
Abstract
Objective: To compare the effectiveness of positional therapy (PT) with the sleep position trainer (SPT) to oral appliance therapy (OAT) in patients with mild-to-moderate positional obstructive sleep apnea (POSA). Methods: Multicenter, prospective, randomized, controlled trial. Patients with mild-to-moderate POSA (apnea-hypopnea index (AHI) >= 5 <= 30/hour sleep) were randomized for PT or OAT. Polysomnography was repeated after 3 months. Efficacy, adherence, mean disease alleviation (MDA), quality of life, dropouts and adverse events were evaluated. Results: A total of 177 patients were screened for the study; 99 underwent randomization and 81 completed the study. Intention-to-treat (ITT) analysis of median [IQR] AHI showed a reduction in the PT group from 13.0 [9.7-18.5] to 7.0 [3.8-12.8], p < 0.001 and in the OAT group from 11.7 [9.0-16.2] to 9.1 [4.9-11.7], p < 0.001. Mean adherence (>= 4 h/night, >= 5 days/week) was 89.3 +/- 22.4% for SPT versus 81.3 +/- 30.0% in OAT patients, p = 0.208. Conclusions: Oral appliance therapy and positional therapy were equally effective in reducing the median AHI in patients with mild-to-moderate POSA. The results of this study have important implications for future OSA treatment guidelines and daily clinical practice. (C) 2017 Elsevier B.V. All rights reserved.
Language
English
Source (journal)
Sleep medicine. - Amsterdam
Publication
Amsterdam : 2017
ISSN
1389-9457
DOI
10.1016/J.SLEEP.2017.01.024
Volume/pages
34 (2017) , p. 109-117
ISI
000402353400018
Pubmed ID
28522078
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 13.07.2017
Last edited 04.03.2024
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