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Title
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Epitope analysis of DQ6-reactive antibodies in sera from a DQ6-positive transplant candidate sensitized during pregnancy
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Author
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Abstract
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| This case report describes DQ6-reactive serum antibody reactivity in a patient who types as DQ6. DNA typing showed DQB1*06:09 on the antibody producer and serum reactivity with DQB1*06:01, *06:02 and *06:03 but not with *06:04 and *06:09. HLAMatchmaker serum analysis showed antibody reactivity with a new antibody verified 85VA eplet on DQB but additional reactivity with DQB1*02:01 could not be readily interpreted. After applying the nonself-self algorithm of HLA immunogenicity we have identified a new DQB epitope structurally described as 140A(2) + 130R + 135D and shared by DQB1*02:01 and DQB1*05:01 and DQB1*06:02 of the immunizer. (C) 2016 Elsevier B.V. All rights reserved. |
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Language
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English
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Source (journal)
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Transplant immunology. - Sevenoaks
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Publication
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Sevenoaks
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2016
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ISSN
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0966-3274
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DOI
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10.1016/J.TRIM.2016.07.004
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Volume/pages
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38
(2016)
, p. 15-18
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ISI
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000384787000003
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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