Title
|
|
|
|
Plasma anti-glial fibrillary acidic protein autoantibody levels during the acute and chronic phases of traumatic brain injury : a transforming research and clinical knowledge in traumatic brain injury pilot study
| |
Author
|
|
|
|
| |
Institution/Organisation
|
|
|
|
TRACK-TBI Investigators
| |
Abstract
|
|
|
|
We described recently a subacute serum autoantibody response toward glial fibrillary acidic protein (GFAP) and its breakdown products 5-10 days after severe traumatic brain injury (TBI). Here, we expanded our anti-GFAP autoantibody (AutoAb[GFAP]) investigation to the multicenter observational study Transforming Research and Clinical Knowledge in TBI Pilot (TRACK-TBI Pilot) to cover the full spectrum of TBI (Glasgow Coma Scale 3-15) by using acute (<24 h) plasma samples from 196 patients with acute TBI admitted to three Level I trauma centers, and a second cohort of 21 participants with chronic TBI admitted to inpatient TBI rehabilitation. We find that acute patients self-reporting previous TBI with loss of consciousness (LOC) (n = 43) had higher day 1 AutoAb [GFAP] (mean +/- standard error: 9.11 +/- 1.42; n = 43) than healthy controls (2.90 +/- 0.92; n = 16;p = 0.032) and acute patients reporting no previous TBI (2.97 +/- 0.37; n = 106; p < 0.001), but not acute patients reporting previous TBI without LOC (8.01 +/- 1.80; n = 47; p = 0.906). These data suggest that while exposure to TBI may trigger the AutoAb[GFAP] response, circulating antibodies are elevated specifically in acute TBI patients with a history of TBI. AutoAb[GFAP] levels for participants with chronic TBI (average post-TBI time 176 days or 6.21 months) were also significantly higher (15.08 +/- 2.82; n = 21) than healthy controls (p < 0.001). These data suggest a persistent upregulation of the autoimmune response to specific brain antigen(s) in the subacute to chronic phase after TBI, as well as after repeated TBI insults. Hence, AutoAb [GFAP] may be a sensitive assay to study the dynamic interactions between post injury brain and patient-specific autoimmune responses across acute and chronic settings after TBI. |
| |
Language
|
|
|
|
English
| |
Source (journal)
|
|
|
|
Journal of neurotrauma. - New York
| |
Publication
|
|
|
|
New York
:
2016
| |
ISSN
|
|
|
|
1557-9042
[online]
0897-7151
[print]
| |
DOI
|
|
|
|
10.1089/NEU.2015.3881
| |
Volume/pages
|
|
|
|
33
:13
(2016)
, p. 1270-1277
| |
ISI
|
|
|
|
000378336200393
| |
Full text (Publisher's DOI)
|
|
|
|
| |
Full text (publisher's version - intranet only)
|
|
|
|
| |
|