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Title
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Biometry and visual function of a healthy cohort in Leipzig, Germany
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Author
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Institution/Organisation
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EVICR Net
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Abstract
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| Background: Cross-sectional survey of ocular biometry and visual function in healthy eyes across the life span of a German population aged 20 to 69 years (n = 218). Subject number in percent per age category reflected the percentage within the respective age band of the population of Leipzig, Germany. Methods: Measurements obtained: subjective and objective refraction, best-corrected visual acuity, accommodation, contrast sensitivity, topography and pachymetry with Scheimpflug camera, axial length with non-contact partial coherence interferometry, and spectral-domain optical coherence tomography of the retina. Pearson correlation coefficients with corresponding p-values were given to present interrelationships between stature, biometric and refractive parameters or their associations with age. Two-sample T-tests were used to calculate gender differences. The area under the logarithmic contrast sensitivity function (AULCSF) was calculated for the analysis of contrast sensitivity as a single figure across a range of spatial frequencies. Results: The results of axial length (AL), anterior chamber depth (ACD) and anterior chamber volume (ACV) differed as a function of the age of the participants (rho (p value): AL -0.19 (0.006), ACD -0.56 (<0.001), ACV-0.52 (<0.001)). Longer eyes had deeper ACD (AL: ACD 0.62 (<0.001), greater ACV (AL: ACV 0.65 (<0.001) and steeper corneal radii (AL:R1ant; R2ant; R1post; R2post 0.40; 0.35; 0.36; 0.36 (all with (<0.001)). Spherical equivalent was associated with age (towards hyperopia: 0.34 (<0.001)), AL (-0.66 (<0.001)), ACD (-0.52 (<0.001)) and ACV (-0.46 (<0.001)). Accommodation was found lower for older subjects (negative association with age, r = -0.82 (<0.001)) and contrast sensitivity presented with smaller values for older ages (AULCSF -0.38, (<0.001)), no change of retinal thickness with age. 58 % of the study cohort presented with a change of refractive correction above +/- 0.50 D in one or both eyes (64 % of these were habitual spectacle wearers), need for improvement was present in the young age-group and for older subjects with increasing age. Conclusion: Biometrical data of healthy German eyes, stratified by age, gender and refractive status, enabled cross-comparison of all parameters, providing an important reference database for future patient-based research and specific in-depth investigations of biometric data in epidemiological research. |
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Language
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English
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Source (journal)
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BMC ophthalmology. - London
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Publication
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London
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2016
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ISSN
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1471-2415
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DOI
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10.1186/S12886-016-0232-2
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Volume/pages
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16
(2016)
, 20 p.
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Article Reference
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79
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ISI
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000377535100003
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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