Publication
Title
Large-scale phylogenomics of the **Lactobacillus casei** group highlights taxonomic inconsistencies and reveals novel clade-associated features
Author
Abstract
Although the genotypic and phenotypic properties of the Lactobacillus casei group have been studied extensively, the taxonomic structure has been the subject of debate for a long time. Here, we performed a large-scale comparative analysis by using 183 publicly available genomes supplemented with a Lactobacillus strain isolated from the human upper respiratory tract. On the basis of this analysis, we identified inconsistencies in the taxonomy and reclassified all of the genomes according to their most closely related type strains. This led to the identification of a catalase-encoding gene in all 10 L. casei sensu stricto strains, making it the first described catalase-positive species in the Lactobacillus genus. Moreover, we found that 6 of 10 L. casei genomes contained a SecA2/SecY2 gene cluster with two putative glycosylated surface adhesin proteins. Altogether, our results highlight current inconsistencies in the taxonomy of the L. casei group and reveal new clade-associated functional features.
Language
English
Source (journal)
mSystems. - [S.l.]
Publication
[S.l.] : ASM , 2017
ISSN
2379-5077
DOI
10.1128/MSYSTEMS.00061-17
Volume/pages
2 :4 (2017) , 16 p.
Article Reference
e00061-17
UNSP e00061-17
ISI
000408197100011
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
ProCure : Defining the future of probiotics for upper respiratory tract diseases.
Integrated 'omics' approach of fermented vegetable juices.
Microbiome analysis of the upper respiratory tract: identification of beneficial microbes with probiotic potential.
CalcUA as central calculation facility: supporting core facilities.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 26.09.2017
Last edited 22.01.2024
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