Publication
Title
Immunomodulating and anti-allergic effects of negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Author
Abstract
Polyphenols contained in FGM from Negroamaro (N) and Koshu (K) Vitis vinifera have been shown to exhibit several immunomodulating activities. For instance, mice affected by experimental colitis when administered with K-FGM showed an attenuation of the inflammatory process. In murine asthma, K-FGM reduced IgE production and eosinophil number in bronchial alveolar lavage fluid. In vitro, both N-and K-FGM were able to induce T regulatory cells in terms of Foxp-3 molecule expression and release of interleukin-10. In another set of experiments both N-and K-FGM were able to balance rate of proliferation/apoptosis/necrosis of normal human peripheral lymphocytes, thus indicating the property of these compounds to maintain immune homeostatic mechanisms in the host. On the other hand, N-and K-FGM inhibited human basophil degranulation, thus, confirming our previous results obtained with rat basophilic leukemia cells. Finally, N-and K-FGM also decreased oxidative burst of human polymorphonuclear cells and monocytes. Taken together, these findings imply the potential clinical usefulness of FGM administration in inflammatory/allergic conditions, such as chronic asthma.
Language
English
Source (journal)
Current pharmaceutical design. - Schiphol, 1995, currens
Publication
Schiphol : Bentham Science Publishers , 2014
ISSN
1381-6128 [print]
1873-4286 [online]
DOI
10.2174/138161282006140220120640
Volume/pages
20 :6 (2014) , p. 864-868
ISI
000334306800006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Project info
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 19.10.2017
Last edited 04.03.2024
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