Title
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Immunomodulating and anti-allergic effects of negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
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Author
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Abstract
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Polyphenols contained in FGM from Negroamaro (N) and Koshu (K) Vitis vinifera have been shown to exhibit several immunomodulating activities. For instance, mice affected by experimental colitis when administered with K-FGM showed an attenuation of the inflammatory process. In murine asthma, K-FGM reduced IgE production and eosinophil number in bronchial alveolar lavage fluid. In vitro, both N-and K-FGM were able to induce T regulatory cells in terms of Foxp-3 molecule expression and release of interleukin-10. In another set of experiments both N-and K-FGM were able to balance rate of proliferation/apoptosis/necrosis of normal human peripheral lymphocytes, thus indicating the property of these compounds to maintain immune homeostatic mechanisms in the host. On the other hand, N-and K-FGM inhibited human basophil degranulation, thus, confirming our previous results obtained with rat basophilic leukemia cells. Finally, N-and K-FGM also decreased oxidative burst of human polymorphonuclear cells and monocytes. Taken together, these findings imply the potential clinical usefulness of FGM administration in inflammatory/allergic conditions, such as chronic asthma. |
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Language
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English
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Source (journal)
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Current pharmaceutical design. - Schiphol, 1995, currens
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Publication
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Schiphol
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Bentham Science Publishers
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2014
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ISSN
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1381-6128
[print]
1873-4286
[online]
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DOI
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10.2174/138161282006140220120640
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Volume/pages
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20
:6
(2014)
, p. 864-868
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ISI
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000334306800006
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Full text (Publisher's DOI)
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