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Title
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The effect of diet or exercise on ectopic adiposity in children and adolescents with obesity : a systematic review and meta-analysis
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Author
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Abstract
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| Objective: Ectopic fat depostion in youth with obesity is associated with an increased cardiovascular disease risk. The aim of this meta-analysis was to summarize the evidence for the use of diet and/or exercise on ectopic adiposity in this population. Methods: A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Clinical trials that assessed ectopic fat deposition and included study arms with diet and/or exercise were searched in PubMed, PEDro and the Cochrane database. Results: Hepatic fat content and intramyocellular lipid content were described in nine studies and three studies, respectively. Most studies included teenagers, and study duration ranged between 3 and 12 months without follow-up. Using random-effects weights, the standardized mean difference of the change in hepatic adiposity (totalling 320 subjects) was -0.54 Hedges' g (95% confidence interval: -0.69 to -0.38 with p<0.0001). By re-expressing this effect size, it is seen that diet and/or exercise results in an absolute reduction of intrahepatic lipid with 2%, which accords with a relative reduction up to 70%. Although there were significant ameliorations of insulin sensitivity, no significant changes in intramyocellular lipid were observed. Conclusions: This meta-analysis showed that diet and/or exercise is effective to reduce hepatic adiposity in youth with obesity. |
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Language
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English
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Source (journal)
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Obesity reviews. - Oxford
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Publication
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Hoboken
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Wiley
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2017
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ISSN
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1467-7881
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DOI
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10.1111/OBR.12577
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Volume/pages
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18
:11
(2017)
, p. 1310-1322
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ISI
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000412643600006
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Pubmed ID
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28913977
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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