Publication
Title
Salivary DNA methylation profiling : aspects to consider for biomarker identification
Author
Abstract
Is it not more comfortable to spit saliva in a tube than to be pricked with a needle to draw blood to analyse your health and disease risk? Many patients, study participants and (parents of) young children undoubtedly prefer non-invasive and convenient procedures. Such procedures increase compliance rates especially for longitudinal prospective studies. Saliva is an attractive biofluid providing good quality DNA to study epigenetic mechanisms underlying disease across development. In this MiniReview, we will describe the different applications of saliva in the field of epigenetics, focusing on genomewide methylation analysis. Advantages of the use of saliva and its comparability with blood will be discussed, as will the challenges in data processing and interpretation. Knowledge gaps will be identified and suggestions given on how to improve the analysis, making saliva 'the' biofluid of choice for future biomarker initiatives in many different epidemiological and public health studies.
Language
English
Source (journal)
Basic and clinical pharmacology and toxicology. - Copenhagen
Source (book)
Annual Meeting of the, European-Environmental-Mutagenesis-and-Genomics-Society (EEMGS), AUG 14-18, 2016, Copenhagen, DENMARK
Publication
Hoboken : Wiley , 2017
ISSN
1742-7835
DOI
10.1111/BCPT.12721
Volume/pages
121 :s:[3] (2017) , p. 93-101
ISI
000411036200011
Pubmed ID
27901320
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Investigation of epigenetic suppressor and enhancer mechanisms of glucocorticoid induced therapy response in leukemia.
Quantitative proteomic characterization of cellular targets of withaferin A involved in cancer therapy chemosensitisation in B-cell chronic leukemia cells.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 07.11.2017
Last edited 28.01.2024
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