Title
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Failed downregulation of circulating MicroRNA-155 in the early phase after ST elevation myocardial infarction is associated with adverse left ventricular remodeling
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Author
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Abstract
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Background: MicroRNA are noncoding RNA that have a significant role in both inflammatory and cardiovascular diseases. Aims: We aimed to assess whether the inflammation related microRNA-155 is associated with the development of adverse left ventricular (LV) remodeling following ST elevation myocardial infarction (STEMI). Methods: Peripheral blood samples were collected in the inflammatory (day 2), proliferative (day 5), and maturation phases (6 months) after STEMI (n = 20). Granulocytes, monocytes, and lymphocytes were enumerated with flow cytometry. The changes in LV volumes were assessed with 3-D echocardiography on day 1 and after 6 months. Adverse remodeling was defined as a >20% increase in end-diastolic volume. Healthy subjects were recruited as controls. Results: MicroRNA-155 measured on days correlated positively with the relative change in end-diastolic volume (p = 0.490,p = 0.028). MicroRNA-155 (day 5) was significantly higher in patients with compared to patients without adverse LV remodeling. The expression level was similar in healthy subjects (n = 8) and in patients with LV remodeling. There was a positive correlation between rnicroRNA-155 and the amount of monocytes (days, p = 0.463, p = 0.046). Conclusion: Impaired downregulation of microRNA-155 during the second phase of the post-STEMI inflammatory response is a determinant of the development of adverse LV remodeling. (C) 2017 S. Karger AG, Basel |
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Language
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English
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Source (journal)
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Cardiology. - Basel
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Publication
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Basel
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2017
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ISSN
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0008-6312
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DOI
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10.1159/000477235
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Volume/pages
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138
:2
(2017)
, p. 91-96
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ISI
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000410875100007
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Pubmed ID
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28618412
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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