Title
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Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors
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Author
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Abstract
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Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents, whose mechanism of action is based mainly on interference with the activity of transcription Factors, such us nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1). The precise molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due to the existence of many conflicting hypotheses. We discuss the three main paradigms reported in the literature, namely the inhibitor kappa B-alpha (I kappa B-alpha) upregulatory model, the protein-protein interaction model and the competition model. (C) 2000 Elsevier Science BN. All rights reserved. |
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Language
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English
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Source (journal)
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Journal of neuroimmunology. - Amsterdam
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Publication
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Amsterdam
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2000
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ISSN
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0165-5728
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DOI
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10.1016/S0165-5728(00)00297-6
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Volume/pages
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109
:1
(2000)
, p. 16-22
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ISI
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000089322000004
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Full text (Publisher's DOI)
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