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Title
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Innovative approach to the design and evaluation of treatment adherence interventions for drug-resistant TB
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Author
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Abstract
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| BACKGROUND: Drug-resistant tuberculosis (DR-TB) treatment is expensive, lengthy, and can cause severe side effects. Patients face socio-economic, psychosocial, and systemic barriers to adherence; poor adherence results in poor treatment outcomes. OBJECTIVE : To estimate the effects of the components of the information-motivation-behavioral skills model on DR-TB treatment adherence. DESIGN: We recruited 326 adults receiving DR-TB treatment and 86 of their health care service providers from 40 health centers in Lima, Peru. The main outcome was adherence (i.e., the proportion of prescribed doses taken by a patient). Exposure measures were adherence information, motivation, and behavioral skills; loss to follow-up during previous TB treatment(s); providers' work engagement; and patient-perceived support from his/her social network. RESULTS : Structural equation modeling revealed that adherence information and motivation had positive effects on adherence, but only if mediated through behavioral skills (beta = 0.02, P < 0.01 and beta = 0.07, P < 0.001, respectively). Behavioral skills had a direct positive effect on adherence (beta = 0.27, P < 0.001). Loss to followup during previous treatment had a direct negative effect, providers' work engagement had a direct positive effect, and perceived support had indirect positive effects on adherence. The model's overall R-2 was 0.76. CONCLUSION: The components of the information-motivation-behavioral skills model were associated with adherence and could be used to design, monitor, and evaluate interventions targeting adherence to DR-TB treatment. |
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Language
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English
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Source (journal)
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International journal of tuberculosis and lung disease. - Paris
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Publication
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Paris
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2017
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ISSN
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1027-3719
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DOI
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10.5588/IJTLD.17.0296
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Volume/pages
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21
:11
(2017)
, p. 1160-+
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ISI
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000414026100012
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Pubmed ID
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29037297
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Full text (Publisher's DOI)
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