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Title
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Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study
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Author
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Abstract
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| Background. Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence of pertussis among Thai infants in recent years led us to examine the preexisting antibodies to Bordetella pertussis antigens in a cohort of 90 pregnant women. Methods. We evaluated the IgG to the Pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) in maternal and cord blood sera using commercial enzyme-linked immunosorbent assays (ELISA). Results. When values of > 10 IU/ml were accepted as potential protective concentrations, we found that the percentages of unprotected infants were 73.3%, 43.3% and 75.5% for anti-PT, anti-FHA and anti-PRN IgG, respectively. Discussion. These results may explain the susceptibility for pertussis among newborn infants in Thailand and support the requirement for a pertussis booster vaccine during pregnancy, which may contribute to the passive seroprotection among newborns during the first months of life. |
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Language
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English
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Source (journal)
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PeerJ
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Publication
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2017
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ISSN
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2167-8359
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DOI
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10.7717/PEERJ.4043
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Volume/pages
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5
(2017)
, 12 p.
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Article Reference
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e4043
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ISI
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000416048100002
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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