Publication
Title
Genotoxicity and antigenotoxicity of selected South African indigenous plants
Author
Abstract
Twenty-two plant species extracted with dichloromethane and 90% methanol were investigated for their genotoxicity as well as antigenotoxicity against aflatoxin B1 induced-mutagenicity using the Ames (Salmonella typhimurium strains TA98 and TA100) and Vitotox assays in the presence of S9 rat liver fraction. The results obtained from Ames assay for some plant extracts correlated well with the results obtained from the Vitotox assay. Dichloromethane and methanolic extracts of Helichrysum petiolare, Protea hybrid, Protea roupelliae, Artabotrys brachypetalus (leaves), Friesodielsia obovata, Hexalobus monopetalus, Monanthotaxis caffra, Monodora junodis, Uvaria caffra, Xylopia parviflora, Podocarpus henkellii, Rhoicissus sekhukhuniensis, Podocarpus elongatus and Agapanthus praecox had moderate to strong antimutagenic activities in both Ames and Vitotox assays. The methanolic extract of Annona senegalensis and dichloromethane extract of Podocarpus falcutus also showed antigenotoxic potentials against aflatoxin B1 induced mutagenicity. Methanolic extracts of Xylopia sp., showed a co-mutagenic effect with aflatoxin B1 in the Ames assay (strain TA100). All extracts were not genotoxic in the Vitotox assay in the absence of S9. Plant extracts with promising antimutagenic effects could be used in the form of feed and food supplements as a preventative strategy against aflatoxin B1 induced mutagenicity and carcinogenicity.
Language
English
Source (journal)
South African journal of botany. - Capetown
Publication
Capetown : 2018
ISSN
0254-6299
DOI
10.1016/J.SAJB.2017.10.016
Volume/pages
114 (2018) , p. 89-99
ISI
000419710000014
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 15.01.2018
Last edited 09.10.2023
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