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Title
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Development and validation of a quantitative UHPLC-MS/MS method for selected brominated flame retardants in food
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Author
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Abstract
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| An ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated (in-house) for the quantification of selected brominated flame retardants (BFRs), including tetrabromobisphenol A (TBBPA), hexabromocyclododecanes (HBCDs), tetrabromobisphenol S (TBBPS) and bromophenols (BPs), in various food matrices. The sample preparation consisted of extraction of TBBPS with acidified acetonitrile followed by a fast dispersive solid-phase extraction (dSPE) clean-up and extraction of the other BFRs with a mixture of hexane and dichloromethane (1:1, v/v) with subsequent clean-up using acidified silica (44%, w/w). The limits of quantification of the method varied widely for the types of food matrices and the different classes of BFRs from 4 pg g−1 wet weight (ww) to 8 ng g−1 ww. For most of the analytes the apparent recovery was in the range 70120%, and the method precision (under repeatability conditions) was below 20%. The method was successfully applied in proficiency testing exercises as well as for analysis of various food items. Only 25% of the collected food samples contained BFRs, with 4-bromophenol and α-HBCD as the only detected compounds. The contaminated foodstuffs were fish and eggs with concentrations in the range from 48 to 305 pg g−1 ww. |
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Language
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English
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Source (journal)
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Food additives and contaminants : part A : chemistry, analysis, control, exposure and risk assessment. - Abingdon
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Publication
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Abingdon
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2018
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ISSN
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1944-0049
1944-0057
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DOI
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10.1080/19440049.2017.1393110
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Volume/pages
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35
:2
(2018)
, p. 292-304
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ISI
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000424170300011
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Pubmed ID
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29087783
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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