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Title
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Xpert (R) MTB/RIF for point-of-care diagnosis of TB in high-HIV burden, resource-limited countries : hype or hope?
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Author
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Abstract
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| Despite the identification of Mycobacterium tuberculosis as the cause of tuberculosis (TB) more than a century ago, diagnosing TB in resource-poor countries remains a challenge, especially in people living with HIV. In the past decade, important research investments have been made towards the development of new diagnostics for TB and the Xpert (R) MTB/RIF assay (Cepheid, CA, USA) has emerged as one of the most promising. In this article, we review the current knowledge on Xpert MTB/RIF, discuss the potential value of Xpert MTB/RIF as a point-of-care diagnostic for drug-sensitive and drug-resistant TB, and outline the potential indications for the assay in resource-limited, high-HIV burden settings. We also discuss key research questions that need to be addressed prior to possible large-scale implementation of the assay. |
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Language
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English
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Source (journal)
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Expert review of molecular diagnostics
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Publication
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London
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Expert reviews
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2010
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ISSN
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1473-7159
1744-8352
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DOI
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10.1586/ERM.10.67
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Volume/pages
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10
:7
(2010)
, p. 937-946
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ISI
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000284498300011
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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