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Title
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Transmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling "strain W" among noninstitutionalized, human immunodeficiency virus-seronegative patients
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Author
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Abstract
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| Since 1990, several outbreaks of multidrug-resistant tuberculosis (MDR-TB) have been described among institutionalized patients infected with human immunodeficiency virus (HIV). We describe a community MDR-TB outbreak among HIV-seronegative patients in Cape Town, South Africa. Isolates were characterized by restriction fragment length polymorphism (RFLP) analysis and dot-blot hybridization analysis of mutations conferring resistance for isoniazid, rifampin, streptomycin, and ethambutol, All isolates were identical on RFLP analysis, In 2 patients, RFLP analysis showed exogenous reinfection during or after treatment for drug-susceptible TB, Mutation analysis confirmed the genotypic identity of the isolates. The infecting strain was genotypically related to strain W which is responsible for the majority of MDR-TB outbreaks in New York City. Transmission of MDR-TB is thus not limited to HIV-seropositive patients in an institutional setting but occurs within a community. |
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Language
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English
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Source (journal)
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The journal of infectious diseases. - Chicago, Ill.
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Publication
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Chicago, Ill.
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1999
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ISSN
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0022-1899
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DOI
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10.1086/315054
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Volume/pages
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180
:5
(1999)
, p. 1608-1615
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ISI
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000083519500026
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Full text (Publisher's DOI)
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