Publication
Title
An integrative translational approach to study heart failure with preserved ejection fraction : a position paper from the Working Group on Myocardial Function of the European Society of Cardiology
Author
Abstract
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.
Language
English
Source (journal)
European journal of heart failure. - Place of publication unknown
Publication
Place of publication unknown : 2018
ISSN
1388-9842 [Print]
1879-0844 [Online]
DOI
10.1002/EJHF.1059
Volume/pages
20 :2 (2018) , p. 216-227
ISI
000429044500005
Pubmed ID
29148148
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 28.02.2018
Last edited 09.10.2023
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