Publication
Title
Sequential multicomponent strategy for the diastereoselective synthesis of densely functionalized spirooxindole-fused thiazolidines
Author
Abstract
We developed two Ugi-type three-component reactions of spirooxindole-fused 3-thiazolines, isocyanides, and either carboxylic acids or trimethylsilyl azide, to give highly functionalized spirooxindole-fused thiazolidines. Two diverse libraries were generated using practical and robust procedures affording the products in typically good yields. The obtained thiazolidines proved to be suitable substrates for further transformations. Notably, both the Ugi-Joullie and the azido-Ugi reactions resulted highly diastereoselective, affording predominantly the trans-configured products, as confirmed by X-ray crystallographic analysis.
Language
English
Source (journal)
ACS combinatorial science. - -
Publication
2018
ISSN
2156-8952
2156-8944
DOI
10.1021/ACSCOMBSCI.7B00179
Volume/pages
20 :2 (2018) , p. 98-105
ISI
000425193200007
Pubmed ID
29323868
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 06.03.2018
Last edited 09.10.2023
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