Publication
Title
Impact of aerobic interval training and continuous training on left ventricular geometry and function : a SAINTEX-CAD substudy
Author
Abstract
Background Increase of exercise capacity (peak VO2) after cardiac rehabilitation improves outcome in patients with coronary artery disease (CAD). Systolic and diastolic function have been associated with peak VO2, but their role towards improvement of exercise capacity remains unclear. It is unknown which exercise intensity has the most beneficial impact on left ventricular (LV) geometry and function in CAD patients without heart failure. Methods 200 stable CAD patients without heart failure were randomized to 3 months of aerobic interval training (AIT) or aerobic continuous training (ACT). Cardiopulmonary exercise test and transthoracic echocardiography were scheduled before and after 3 months of training. Results At baseline, a higher peak VO2 correlated with lower LV posterior wall thickness (p = 0.002), higher LV ejection fraction (p = 0.008), better LV global longitudinal strain (p = 0.043) and lower E/e′ (0 = 0.001). After multivariate stepwise regression analysis only E/é remained an independent predictor of peak VO2 (p = 0.042). Improvement of peak VO2 after 3 months of training correlated with reverse remodeling of the interventricular septum (p = 0.005), enlargement of LV diastolic volume (p = 0.007) and increase of LV stroke volume (p = 0.018) but not with other indices of systolic or diastolic function. Significant reduction of the interventricular septum thickness after cardiac rehabilitation was observed (p = 0.012), with a trend towards more reverse remodeling after ACT compared to AIT (p = 0.054). In contrast, there were no changes in other parameters of LV geometry, diastolic or systolic function. Conclusion Systolic and diastolic function are determinants of baseline exercise capacity in CAD patients without heart failure, but do not seem to mediate improvement of peak VO2 after either AIT or ACT.
Language
English
Source (journal)
International journal of cardiology. - Amsterdam, 1981, currens
Publication
Amsterdam : 2018
ISSN
0167-5273
DOI
10.1016/J.IJCARD.2017.11.053
Volume/pages
257 (2018) , p. 193-198
ISI
000427530200047
Pubmed ID
29506692
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 08.03.2018
Last edited 04.03.2024
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