Publication
Title
Enhancement of cellular glucose uptake by reactive species : a promising approach for diabetes therapy
Author
Abstract
It is generally known that antidiabetic activity is associated with an increased level of glucose uptake in adipocytes and skeletal muscle cells. However, the role of exogenous reactive oxygen and nitrogen species (RONS) in muscle development and more importantly in glucose uptake is largely unknown. We investigate the effect of RONS generated by cold atmospheric plasma (CAP) in glucose uptake. We show that the glucose uptake is significantly enhanced in differentiated L6 skeletal muscle cells after CAP treatment. We also observe a significant increase of the intracellular Ca++ and ROS level, without causing toxicity. One of the possible reasons for an elevated level of glucose uptake as well as intracellular ROS and Ca++ ions is probably the increased oxidative stress leading to glucose transport.
Language
English
Source (journal)
RSC advances
Publication
2018
ISSN
2046-2069
DOI
10.1039/C7RA13389H
Volume/pages
8 :18 (2018) , p. 9887-9894
ISI
000430451800036
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Towards a fundamental understanding of plasma for cancer treatment: A combined experimental and computational study.
Atomic scale modeling for plasma cancer treatment.
ANTICANCER-PAM: Anticancer activity of plasma activated medium and its underlying mechanisms: Combined experimental and computational study
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 14.03.2018
Last edited 09.10.2023
To cite this reference