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Title
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Evaluating substance use via wastewater analysis : an overview of analytical workflows
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Author
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Abstract
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| Recently, wastewater analysis, also known as wastewater-based epidemiology (WBE), has become an established approach for retrieving additional epidemiological information for evaluating the use of illicit drugs, alcohol, and tobacco at the population level. WBE relies on the analysis of human metabolites (biomarkers) in urban wastewater to monitor and back-estimate substance use in the studied populations. Biomarkers of interest are typically identified and quantified with target analytical methods using liquid chromatography coupled to tandem mass spectrometry (LCMS/MS). However, high-resolution and accurate mass spectrometry are also used in WBE to perform suspect and nontarget screening for emerging substances, such as new psychoactive substances and their metabolites, in wastewater and public urinals. This article presents an overview of the recent analytical frameworks and workflows for target and suspect analyses using low- and high-resolution mass spectrometry and discusses the latest advances in WBE. Finally, it briefly discusses future perspectives and developments. |
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Language
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English
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Source (journal)
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LC-GC North America: Special Issues
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Publication
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2017
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Volume/pages
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35
:10
(2017)
, p. 14-20
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Full text (open access)
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Full text (publisher's version - intranet only)
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