Publication
Title
The role of whole-brain diffusion MRI as a tool for studying human in vivo cortical segregation based on a measure of neurite density
Author
Abstract
PurposeTo investigate whether diffusion MRI can be used to study cortical segregation based on a contrast related to neurite density, thus providing a complementary tool to myelin-based MRI techniques used for myeloarchitecture. MethodsSeveral myelin-sensitive MRI methods (e.g., based on T-1, T-2, and T2*) have been proposed to parcellate cortical areas based on their myeloarchitecture. Recent improvements in hardware, acquisition, and analysis methods have opened the possibility of achieving a more robust characterization of cortical microstructure using diffusion MRI. High-quality diffusion MRI data from the Human Connectome Project was combined with recent advances in fiber orientation modeling. The orientational average of the fiber orientation distribution was used as a summary parameter, which was displayed as inflated brain surface views. ResultsDiffusion MRI identifies cortical patterns consistent with those previously seen by MRI methods used for studying myeloarchitecture, which have shown patterns of high myelination in the sensorimotor strip, visual cortex, and auditory areas and low myelination in frontal and anterior temporal areas. ConclusionIn vivo human diffusion MRI provides a useful complementary noninvasive approach to myelin-based methods used to study whole-brain cortical parcellation, by exploiting a contrast based on tissue microstructure related to neurite density, rather than myelin itself. Magn Reson Med 79:2738-2744, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.
Language
English
Source (journal)
Magnetic resonance in medicine. - Orlando, Fla
Publication
Orlando, Fla : 2018
ISSN
0740-3194
Volume/pages
79:5(2018), p. 2738-2744
ISI
000425740900028
Pubmed ID
28921634
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Generalised spherical deconvolution of diffusion MRI data for improved microstructural specificity and higher resolution imaging of white matter.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 29.03.2018
Last edited 15.07.2021
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