Publication
Title
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in mice before prominent plaque deposition
Author
Abstract
Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimers disease (AD), but their role in functional impairment is still debated. High levels of APP and APP fragments in mice that overexpress APP might confound their use in preclinical research. We examined the occurrence of behavioral, cognitive and neuroimaging changes in APPNL−G−F knock-in mice that display Aβ42 amyloidosis in the absence of APP overexpression. Female APPNL−G−F mice (carrying Swedish, Iberian and Arctic APP mutations) were compared to APPNL mice (APP Swedish) at 3, 7 and 10 months. Mice were subjected to a test battery that referred to clinical AD symptoms, comprising cage activity, open field, elevated plus maze, social preference and novelty test, and spatial learning, reversal learning and spatial reference memory performance. Our assessment confirmed that behavior at these early ages was largely unaffected in these mice in accordance with previous reports, with some subtle behavioral changes, mainly in social and anxiety-related test performance. Resting-state functional MRI (rsfMRI) assessed connectivity between hippocampal and prefrontal regions with an established role in flexibility, learning and memory. Increased prefrontal-hippocampal network synchronicity was found in 3-month-old APPNL−G−F mice. These functional changes occurred before prominent amyloid plaque deposition.
Language
English
Source (journal)
Behavioural brain research. - Amsterdam
Publication
Amsterdam : 2019
ISSN
0166-4328
Volume/pages
364(2019), p. 431-441
ISI
000463130800047
Pubmed ID
29158112
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 26.04.2018
Last edited 15.07.2021
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