Publication
Title
Assessment of forces in intradermal injection devices : hydrodynamic versus human factors
Author
Abstract
Purpose The force that has to be exerted on the plunger for administering a given amount of fluid in a given time, has an important influence on comfort for the subject and usability for the administrator in intradermal drug delivery. The purpose of this study is to model those forces that are subject-independent, by linking needle and syringe geometry to the force required for ejecting a given fluid at a given ejection rate. Material and Methods We extend the well-known Hagen-Poiseuille formula to predict pressure drop induced by a fluid passing through a cylindrical body. The model investigates the relation between the pressure drop in needles and the theoretic Hagen-Poiseuille prediction and is validated in fifteen needles from 26G up to 33G suited for intradermal drug delivery. We also provide a method to assess forces exerted by operators in real world conditions. Results The model is highly linear in each individual needle with R-square values ranging from 75% up to 99.9%. Ten out of fifteen needles exhibit R-square values above 99%. A proof-of-concept for force assessment is provided by logging forces in operators in real life conditions. Conclusions The force assessment method and the model can be used to pinpoint needle geometry for intradermal injection devices, tuning comfort for subjects and usability for operators.
Language
English
Source (journal)
Pharmaceutical research / American Association of Pharmaceutical Scientists. - New York
Pharmaceutical research / American Association of Pharmaceutical Scientists. - New York
Publication
New York : 2018
ISSN
0724-8741
Volume/pages
35 :6 (2018) , p. 1-12
Article Reference
120
UNSP 120
ISI
000430933700009
Pubmed ID
29671074
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Accuracy of vibrotactile feedforward for posture and motion steering.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.05.2018
Last edited 20.09.2021
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