Publication
Title
Is non-response to fluconazole maintenance therapy for recurrent Candida vaginitis related to sensitization to atopic reactions?
Author
Abstract
ProblemIs sensitization to atopic reaction related to treatment response of recurrent Candida vulvovaginal (RVVC)? Method of the studyAnalysis of ReCiDiF trial data of optimal (OR) and non-responders (NR) to fluconazole maintenance treatment, to explore medical history, physical status, family history, and vaginal immune response for potential sensitization to atopic reaction. ResultsSociodemographic characteristics of 33 NR women were not different from 38 OR. NR had received higher number of different treatments (mean difference 1.6 different treatments (95% CI: 0.20-2.97), P=.03) and had more episodes of disease (P<.05). Multivariate regression analysis showed that family history of atopy (OR: 4.9, CI 95%: 1.1-22.2), duration of symptoms (OR: 1.2, CI 95%: 1.02-1.5), and vulvar excoriation (OR: 3.6, CI 95%: 1.4-9.3) were related to non-response. Vulvar excoriation at entry was the only statistically significant predictive factor for non-response in multivariate analysis with specificity 77.8% and sensitivity 51.6%. ConclusionWomen with RVVC with vulvar excoriation, longer duration of disease, and family history of atopic disease are at increased risk not to respond to maintenance fluconazole treatment.
Language
English
Source (journal)
American journal of reproductive immunology / American Society for the Immunology of Reproduction. - New York, 1989, currens
Publication
New York : 2018
ISSN
1046-7408
Volume/pages
79 :4 (2018) , 7 p.
Article Reference
e12811
ISI
000428349300002
Pubmed ID
29469170
Medium
E-only publicatie
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.05.2018
Last edited 15.10.2021
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