|
Title
|
|
|
|
Lower limbic metabotropic glutamate receptor 5 availability in alcohol dependence
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Animal studies suggest an important role for the metabotropic glutamate receptor subtype 5 (mGlu5) in the pathophysiology of alcohol dependence, but direct human evidence is lacking. The goal of this study was to investigate cerebral mGlu5 availability in alcohol-dependent subjects versus controls using F-18-3-fluoro-5-[(pyridin-3-yl) ethynyl] benzonitrile (F-18-FPEB) PET. Methods: Dynamic 90-min F-18-FPEB scans combined with arterial blood sampling were acquired for 16 recently abstinent alcohol-dependent subjects and 32 age-matched controls. Regional mGlu5 availability was quantified by the F-18-FPEB total distribution volume using both a voxel-by-voxel and a volume-of-interest analysis with partial-volume effect correction. Alcohol consumption within the last 3 mo was assessed by questionnaires and by hair ethyl glucuronide analysis. Craving was assessed using the Desire for Alcohol Questionnaire. Results: mGlu5 availability was lower in mainly limbic regions of alcohol-dependent subjects than in controls (P < 0.05, familywise error-corrected), ranging from 14% in the posterior cingulate cortex to 36% in the caudate nucleus. Lower mGlu5 availability was associated with higher hair ethyl glucuronide levels for most regions and was related to a lower level of craving specifically in the middle frontal gyrus, cingulate cortex, and inferolateral temporal lobe. Conclusion: These findings provide human in vivo evidence that limbic mGlu5 has a role in the pathophysiology of alcohol dependence, possibly involved in a compensatory mechanism helping to reduce craving during abstinence. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
The Journal of nuclear medicine. - New York
| |
|
Publication
|
|
|
|
New York
:
2018
| |
|
ISSN
|
|
|
|
0161-5505
| |
|
Volume/pages
|
|
|
|
59
:4
(2018)
, p. 682-690
| |
|
ISI
|
|
|
|
000428981100035
| |
|
Pubmed ID
|
|
|
|
29348321
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|