Publication
Title
To the brain and back : migratory paths of dendritic cells in multiple sclerosis
Author
Abstract
Migration of dendritic cells (DC) to the central nervous system (CNS) is a critical event in the pathogenesis of multiple sclerosis (MS). While up until now, research has mainly focused on the transmigration of DC through the blood-brain barrier, experimental evidence points out that also the choroid plexus and meningeal vessels represent important gateways to the CNS, especially in early disease stages. On the other hand, DC can exit the CNS to maintain immunological tolerance to patterns expressed in the CNS, a process that is perturbed in MS. Targeting trafficking of immune cells, including DC, to the CNS has demonstrated to be a successful strategy to treat MS. However, this approach is known to compromise protective immune surveillance of the brain. Unravelling the migratory paths of regulatory and pathogenic DC within the CNS may ultimately lead to the design of new therapeutic strategies able to selectively interfere with the recruitment of pathogenic DC to the CNS, while leaving host protective mechanisms intact.
Language
English
Source (journal)
Journal of neuropathology and experimental neurology. - New York, N.Y.
Publication
Cary : Oxford univ press inc , 2018
ISSN
0022-3069
Volume/pages
77 :3 (2018) , p. 178-192
ISI
000428949800001
Pubmed ID
29342287
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Project info
Identification and design of dendritic cells with blood-brain barrier-crossing capacity: moving targets to treat multiple sclerosis (MS)
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.05.2018
Last edited 14.09.2021
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