Publication
Title
Novel natural products for healthy ageing from the mediterranean diet and food plants of other global sources : the MediHealth project
Author
Abstract
There is a rapid increase in the percentage of elderly people in Europe. Consequently, the prevalence of age-related diseases will also significantly increase. Therefore, the main goal of MediHealth, an international research project, is to introduce a novel approach for the discovery of active agents of food plants from the Mediterranean diet and other global sources that promote healthy ageing. To achieve this goal, a series of plants from the Mediterranean diet and food plants from other origins are carefully selected and subjected to in silico, cell-based, in vivo (fly and mouse models), and metabolism analyses. Advanced analytical techniques complement the bio-evaluation process for the efficient isolation and identification of the bioactive plant constituents. Furthermore, pharmacological profiling of bioactive natural products, as well as the identification and synthesis of their metabolites, is carried out. Finally, optimization studies are performed in order to proceed to the development of innovative nutraceuticals, dietary supplements or herbal medicinal products. The project is based on an exchange of researchers between nine universities and four companies from European and non-European countries, exploiting the existing complementary multidisciplinary expertise. Herein, the unique and novel approach of this interdisciplinary project is presented.
Language
English
Source (journal)
Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel
Publication
Bazel : 2018
ISSN
1420-3049
Volume/pages
23:5(2018), 16 p.
Article Reference
1097
ISI
000435204000112
Pubmed ID
29734769
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Novel natural producs for healthy ageing from Mediterranean diet and food plants of other global sources (MediHealth).
Development of an integrated strategy to characterize new lead compounds based on natural pro-drugs and their metabolites.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 07.05.2018
Last edited 15.07.2021
To cite this reference