Publication
Title
Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life
Author
Abstract
To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors. All prevalent end-stage renal disease (ESRD) patients aged 8-18 years who spent at least 6 months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4.0 (PedsQL (TM)) questionnaire. We determined the differences between groups on PedsQL (TM) mean scores, the proportion of children with an impaired HRQoL (ae 1 SD lower than the healthy norm), the proportion of problems on individual items of the PedsQL (TM), and the effect of time on current treatment. Linear regression models were used to explore determinants of HRQoL. 192 out of 278 patients (20% preemptive transplant, 58% non-preemptive transplant, 22% dialysis) filled in the PedsQL (TM) (response rate 69%). Independent of treatment modality, patients had significantly lower mean scores and consequently higher proportions of impaired HRQoL on almost all domains compared to the healthy norm and other chronic health conditions. Patients with a preemptive transplant only reported higher scores on physical health compared to the other treatment modalities. Having comorbidities was the most important determinant associated with lower HRQoL scores. Dialysis and renal transplantation both have a severe impact on the HRQoL of children with ESRD. Physicians should be aware of this continuous burden. Furthermore, to develop tailored interventions for children with ESRD, qualitative studies are needed to gain more insight in the determinants of HRQoL in the different treatment modalities.
Language
English
Source (journal)
Quality of life research. - Oxford
Publication
Oxford : 2018
ISSN
0962-9343
Volume/pages
27 :6 (2018) , p. 1445-1454
ISI
000432222400004
Pubmed ID
29374855
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.06.2018
Last edited 20.09.2021
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