Publication
Title
Short-term angiotensin II treatment affects large artery biomechanics and function in the absence of small artery alterations in mice
Author
Abstract
Induction of hypertension by angiotensin II (Angll) is a widely used experimental stimulus to study vascular aging in mice. It is associated with large artery stiffness, a hallmark of arterial aging and a root cause of increased cardiovascular risk. We reported earlier that long term (4 week) Angll treatment in mice altered the active, contractile properties of the arteries in a vascular bed-specific manner and that, in healthy mice aorta, active contractile properties of the aortic wall determine isobaric aortic stiffness. Given the huge physiological relevance of large artery stiffening, we aimed to characterize the early (1 week) changes in the active properties of the aorta of Angll-treated mice. We were not able to detect a significant effect of Angll treatment on anesthetized blood pressure or abdominal aorta pulse wave velocity Ex vivo biomechanical and functional studies of the aorta revealed increased arterial stiffness and altered vascular smooth muscle cell (VSMC) and endothelial cell reactivity. Interestingly, the Angll-associated changes in the aorta could be largely attributed to alterations in basal VSMC tone and basal nitric oxide efficacy, indicating that, besides structural remodeling of the arterial wall, dysfunctional active components of the aorta play a crucial role in the pathophysiological mechanisms by which Angll treatment induces arterial stiffness.
Language
English
Source (journal)
Frontiers in physiology / Frontiers Research Foundation (Lausanne, Switzerland) - [Lausanne], 2010, currens
Publication
[Lausanne] : Frontiers Research Foundation , 2018
ISSN
1664-042X
Volume/pages
9 (2018) , 11 p.
Article Reference
582
ISI
000432409900001
Pubmed ID
29867592
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Arterial stiffening as a common pathophysiological mechanism in cardiac and kidney failure and brain degeneration.
Preclinical studies on the preventive effects of neuregulin-1 in acute renal failure.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.06.2018
Last edited 20.09.2021
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