Publication
Title
A novel high sensitivity UPLC-MS/MS method for the evaluation of bisphenol A leaching from dental materials
Author
Abstract
There is a growing necessity to acquire more profound knowledge on the quantity of eluates from resinbased dental materials, especially with regard to bisphenol A (BPA). The aim of the present study was to develop a highly sensitive method to characterize the short-term release of BPA in saliva with ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), using an extraction step and additional derivatization of BPA with pyridine-3-sulfonyl chloride. Light-cured resin-based composites were incubated at 37 degrees C in 1 mL artificial saliva, which was refreshed daily for one week. The final protocol allows accurate quantification of very low levels of BPA in samples of artificial saliva (i.e. 1.10 pmol BPA/mL or 250 pg/mL). The daily BPA-release from dental composites, ranging from 1.10 to 7.46 pmol BPA/mL, was characterized over a period of 7 days. The highest total amount of BPA was released from Solitaire 2 (24.72 +/- 2.86 pmol), followed by G-aenial Posterior (15.51 +/- 0.88 pmol) and Filtek Supreme XTE (12.00 +/- 1.31 pmol). In contrast, only trace amounts of BPA were released from Ceram. x Universal. This UPLC-MS/MS method might be used for clinical research focusing on the evaluation of the clinical relevance of BPA release from dental materials.
Language
English
Source (journal)
Scientific reports. - London, 2011, currens
Publication
London : Nature Publishing Group , 2018
ISSN
2045-2322
Volume/pages
8 (2018) , 7 p.
Article Reference
6981
ISI
000431291500033
Pubmed ID
29725047
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Release of Bisphenol A and other endocrine-disruptive compounds from resin-based dental materials.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.06.2018
Last edited 20.09.2021
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